A great deal of drama goes on at Queen's. There is always a major theatrical production in the Michaelmas Term, and operas in conjunction with both Bampton Classical Opera and the Little Opera Company. Lunchtime drama is popular, and Class 3 (Year 7) girls put on a classical play every year in their second term. Individual lessons in preparation for Trinity College Speech and Drama exams are available.

Drama is offered at GCSE and Theatre Studies at A-level, and both are taken by a good number of girls each year.