Girls leaving Queen's go on to a wide variety of different degree courses, and very careful consideration is given to the needs and aspirations of each student. During their I Seniors year (Year 12) all students take the Cambridge Occupational Analysts' 'Centigrade' test and receive a full report detailing possible careers and routes through higher education. There is also an annual careers fair.

The College employs a qualified careers guidance specialist who is available to give advice, and who conducts practice interviews with all II Seniors (Year 13). Those applying to Oxbridge or to medical schools are given additional interview practice. The Head of the Senior College, heads of relevant academic departments, subject teachers and Form Tutors also play an important part in providing constructive advice and support throughout the application period.