Many girls at Queen's learn musical instruments or have individual singing lessons, and there is a full programme of concerts throughout the year including a very popular jazz concert. The Music department is housed in the basement of 47 Harley Street, with the old wine cellars forming very satisfactory instrument stores! There is a well-equipped keyboard lab with a multi-track recording facility.

Girls have regular opportunities for ensemble playing, and in the Easter holidays 2010 the Music department are planning an innovative chamber music trip to Normandy. Opera thrives in the College with productions involving Queen's girls being staged by both Bampton Classical Opera and the Little Opera Company.

Music is a popular choice at GCSE and A-level each year, and Music scholarships are offered at both 11+ and 16+.